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2021-09-05
Division of Neurology, New Jersey Pediatric Neuroscience Institute (NJPNI), Morristown, NJ 07960, USA.; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.; College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Biology, The College of New Jersey, Ewing, NJ 08628, USA.; College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.; School of Arts and Sciences, Rutgers University, New Brunswick, NJ 08901, USA.; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Setting off a global pandemic, coronavirus disease 2019 (COVID-19) has been marked by a heterogeneous clinical presentation that runs the gamut from asymptomatic to severe and fatal. Although less lethal in children than adults, COVID-19 has nonetheless afflicted the pediatric population. This systematic review used clinical information from published literature to assess the spectrum of COVID-19 presentation in children, with special emphasis on characteristics associated with multisystem inflammatory syndrome (MIS-C). An electronic literature search for English and Chinese language articles in COVIDSeer, MEDLINE, and PubMed from 1 January 2020 through 1 March 2021 returned 579 records, of which 54 were included for full evaluation. Out of the total 4811 patients, 543 (11.29%) exhibited MIS-C. The most common symptoms across all children were fever and sore throat. Children presenting with MIS-C were less likely to exhibit sore throat and respiratory symptoms (i.e., cough, shortness