Department of Imaging and Interventional Radiology, The Chinese University of; Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China; Department of Radiology, General hospital of China Resources & Wuhan Iron and; Steel Corporation, Wuhan 430080, China; Research Centre, The Seventh Affiliated Hospital, Sun Yat-sen University,; Shenzhen 518107, China; Department of Radiology, Tongji Hospital, Tongji University School of Medicine,; Shanghai 200065, China;

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

COVID-19 has been spreading worldwide since late 2019. There is no definitive cure to date. Global vaccination programs are urgently required to confer herd immunity, reducing the incidence of COVID-19 infections and associated morbidity and mortality. However, a significant proportion of special populations are hesitant to receive vaccination due to their special conditions, namely, age (pediatrics and geriatrics), immunocompromised state, autoimmune diseases, chronic cardiovascular and pulmonary conditions, active or treated cancers, and pregnancy. This review aims to evaluate the existing evidence of COVID-19 vaccinations on these special populations and to provide clues to guide vaccination decision making to balance the benefits and risks of vaccinations.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong 999077, China.; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.; Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong 999077, China.

The majority of people infected with SARS-CoV-2 fully recovered within a few weeks. However, a considerable number of patients of different ages still suffer from long-lasting problems similar to the multi-organ damage in its acute phase of infection, or experience symptoms continuously for a longer term after the recovery. The severity of the primary infection seems not to be associated with the possibility and severity of long-term symptoms. Various unresolved symptoms have been reported in COVID-19 survivors months after hospital discharge. Long COVID-19 Syndrome refers to survivors 4 months after initial symptoms onset. It is important to understand the systemic effects of Long COVID-19 Syndrome, its presentations, and the need for rehabilitations to restore functional recovery in survivors. Government, healthcare workers, and survivor groups should collaborate to establish a self-sustaining system to facilitate follow-up and rehabilitations, with prioritization of resources to

Department of Imaging and Interventional Radiology, The Chinese University of; Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China; Department of Radiology, General hospital of China Resources & Wuhan Iron and; Steel Corporation, Wuhan 430080, China; Research Centre, The Seventh Affiliated Hospital, Sun Yat-sen University,; Shenzhen 518107, China; Department of Radiology, Tongji Hospital, Tongji University School of Medicine,; Shanghai 200065, China;

2021-07-15

Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.; Gastroenterology Department, Guang'anmen Hospital, China Academy of Chinese Medicine Sciences, Beijing, China.; Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.; Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.; Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Institute for Excellence in Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address: Liujp@bucm.edu.cn.

OBJECTIVES: We aimed to investigate the psychological problems on people infected with SARS-CoV-2 during the pandemic. METHODS: In this living systematic review and meta-analyses, we searched seven electronic databases for cross-sectional studies and longitudinal studies on psychological problems on COVID-19 patients from Jan 1, 2020 to Oct 7, 2020. The primary outcome was prevalence of various psychological problems such as anxiety, depression, stress, insomnia, somatization, and fear. We pooled data for prevalence with their 95% confidence interval (CI) using random effect models and assessed the study quality based on the 11-item checklist recommended by the Agency for Healthcare Research and Quality. RESULTS: Fourty-four studies, including studies from China(35), Italy(2), Iran(2), India(1), Korea(1), Ecuador(1), Switzerland(1), Germany(1), were identified by comprising a total of 8587 completed questionnaires and 38 studies for meta-analyses. The prevalence of anxiety, depression

2021-02-17

Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, China.; Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, China.; Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, China.; Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, China.; Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, China - deerlu23@163.com.

INTRODUCTION: Anesthetic management of parturients with COVID-19 is a big challenge to anesthesiologists. Limited data are available about COVID-19 during pregnancy; however, information on illnesses associated with SARS and MERS might provide insights into COVID-19's effects during pregnancy. EVIDENCE ACQUISITION: Evidence from previous reports from SARS and MERS, and from COVID-19 cases were reviewed. Concepts from guidelines from the government and academic societies were collected as well. EVIDENCE SYNTHESIS: The evidence was described and summarized. CONCLUSIONS: Principles to minimize the risk of infection as well as optimize patients' safety during obstetric anesthesia were found to include careful evaluation, tight protection, and multi-discipline-based strategy. Though vertical transmission of COVID-19 still needs more definitive evidence, strict isolation is necessary for the newborn of COVID-19 mothers. Psychological support for the parturients is also an important issue

2021-10-25

Department of Health Management, School of Health Management, Southern Medical University, Guangzhou, China.; Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.; Department of Health Management, School of Health Management, Southern Medical University, Guangzhou, China.; Department of Health Management, School of Health Management, Southern Medical University, Guangzhou, China.; Department of Health Management, School of Health Management, Southern Medical University, Guangzhou, China.; Department of Health Management, School of Health Management, Southern Medical University, Guangzhou, China.; Department of Health Management, School of Health Management, Southern Medical University, Guangzhou, China.; Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.

Objective: This study aimed to examine the effectiveness of containment strategies and mitigation strategies to provide a reference for controlling the ongoing global spread of the pandemic. Methods: We extracted publicly available data from various official websites between January 1 and December 31, 2020, summarized the strategies implemented in China, South Korea, Singapore, the United States, the United Kingdom, and France, and assessed the effectiveness of the prevention and control measures adopted by these countries with the daily new cases and mortality rate per 100,000 population. Results: China, South Korea, and Singapore adopted containment strategies, which maintained a proactive approach by identifying and managing cases, tracking and isolating close contacts. China and Singapore had a similar epidemic curve and the new daily cases. As of December 31, 2020, the new daily cases of China and Singapore were below 100 with the mortality rates per 100,000 population of 0.3 and

2021-10-05

Graduate School, Beijing University of Chinese Medicine, Beijing, China.; International Medical Services, China-Japan Friendship Hospital, Beijing, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; International Medical Services, China-Japan Friendship Hospital, Beijing, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; International Medical Services, China-Japan Friendship Hospital, Beijing, China.; International Medical Services, China-Japan Friendship Hospital, Beijing, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; International Medical Services, China-Japan Friendship Hospital, Beijing, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; International Medical Services, China-Japan Friendship Hospital, Beijing, China.; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China. niuwenquan_shcn@163.com.

BACKGROUND: We prepared a meta-analysis on case reports in children with COVID-19, aiming to identify potential risk factors for severe illness and to develop a prediction model for risk assessment. METHODS: Literature retrieval, case report selection, and data extraction were independently completed by two authors. STATA software (version 14.1) and R programming environment (v4.0.2) were used for data handling. RESULTS: This meta-analysis was conducted based on 52 case reports, including 203 children (96 boys) with COVID-19. By severity, 26 (12.94%), 160 (79.60%), and 15 (7.46%) children were diagnosed as asymptomatic, mild/moderate, and severe cases, respectively. After adjusting for age and sex, 11 factors were found to be significantly associated with the risk of severe illness relative to asymptomatic or mild/moderate illness, especially for dyspnea/tachypnea (odds ratio, 95% confidence interval, P: 6.61, 4.12-9.09, <0.001) and abnormal chest X-ray (3.33, 1.84-4.82, <0.001). A

2021-09-05

Division of Neurology, New Jersey Pediatric Neuroscience Institute (NJPNI), Morristown, NJ 07960, USA.; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.; College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Biology, The College of New Jersey, Ewing, NJ 08628, USA.; College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.; School of Arts and Sciences, Rutgers University, New Brunswick, NJ 08901, USA.; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

Setting off a global pandemic, coronavirus disease 2019 (COVID-19) has been marked by a heterogeneous clinical presentation that runs the gamut from asymptomatic to severe and fatal. Although less lethal in children than adults, COVID-19 has nonetheless afflicted the pediatric population. This systematic review used clinical information from published literature to assess the spectrum of COVID-19 presentation in children, with special emphasis on characteristics associated with multisystem inflammatory syndrome (MIS-C). An electronic literature search for English and Chinese language articles in COVIDSeer, MEDLINE, and PubMed from 1 January 2020 through 1 March 2021 returned 579 records, of which 54 were included for full evaluation. Out of the total 4811 patients, 543 (11.29%) exhibited MIS-C. The most common symptoms across all children were fever and sore throat. Children presenting with MIS-C were less likely to exhibit sore throat and respiratory symptoms (i.e., cough, shortness

2020-03-04

Department of Pulmonary and Critical Care Medicine, The Xi'an Medical University ; Affiliated Hospital, Xi'an, Shaanxi, PR China Department of Pulmonary and Critical Care Medicine, The Xi'an Medical University ; Affiliated Hospital, Xi'an, Shaanxi, PR China Department of Pulmonary and Critical Care Medicine, The Xi'an Medical University ; Affiliated Hospital, Xi'an, Shaanxi, PR China Department of Pulmonary and Critical Care Medicine, The Xi'an Medical University ; Affiliated Hospital, Xi'an, Shaanxi, PR China Department of Pulmonary and Critical Care Medicine, The Xi'an Medical University ; Affiliated Hospital, Xi'an, Shaanxi, PR China Department of Pulmonary and Critical Care Medicine, The Xi'an Medical University ; Affiliated Hospital, Xi'an, Shaanxi, PR China

In December, 2019, a new coronavirus named 2019-nCoV causing severe acute respiratory disease has emerged in the region of Wuhan, China [1, 2]. The National Health Commission of People's Republic of China named pneumonia infected with 2019-nCoV as Novel Coronavirus Pneumonia (NCP).Evidence have pointing to the person-to-person transmission [3–5]. As of February 8, 2020, China has reported 34 673 confirmed and more than 27 657 suspected cases of NCP across 34 Chinese provinces or municipalities, with 106 fatalities. Most of the studies focused on the epidemic situation in Wuhan, but few on provinces outside Wuhan. Shaanxi is located in the northwest of Hubei Province and adjacent to it, with a population of 38.64 million. Since the first case of NCP was confirmed in Shannxi by on January 23, 2020, 195 cases have been confirmed, but there is no relevant epidemiological study. In order to better understand the epidemic law of new