共检索141条数据Total：141
2021-03-03
Adelphi University College of Nursing and Public Health, Garden City, New York, USA wliu@adelphi.edu jialiu1980@csu.edu.cn.; The Third Xiangya Hospital, Central South University, Changsha, Hunan, China wliu@adelphi.edu jialiu1980@csu.edu.cn.
OBJECTIVES: To describe experiences of hospitalised patients with COVID-19 following family cluster transmission of the infection and the meaning of these experiences for them. DESIGN: A descriptive phenomenological design was used to construct themes depicting patients' experiences of living with COVID-19. SETTING: This study was conducted in a major teaching hospital in Wuhan, China, in March 2020. PARTICIPANTS: Fourteen patients involved in family cluster transmission of COVID-19 were recruited into the study. The participants consisted of seven males and seven females. Data were collected through semistructured, in-depth, face-to-face interviews. Interviews were transcribed verbatim and analysed using Colaizzi's approach. RESULTS: Six themes emerged from data analysis during two distinct phases of patients going through COVID-19: the early outbreak phase and the later hospitalisation phase. Early in the outbreak, patients experienced life imbalances between individual well-being
2021-11-21
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.; Institute for Global Health and Development, Peking University, Beijing, 100871, China.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China. liumin@bjmu.edu.cn.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China. jueliu@bjmu.edu.cn.; Institute for Global Health and Development, Peking University, Beijing, 100871, China. jueliu@bjmu.edu.cn.
BACKGROUND: To date, coronavirus disease 2019 (COVID-19) becomes increasingly fierce due to the emergence of variants. Rapid herd immunity through vaccination is needed to block the mutation and prevent the emergence of variants that can completely escape the immune surveillance. We aimed to systematically evaluate the effectiveness and safety of COVID-19 vaccines in the real world and to establish a reliable evidence-based basis for the actual protective effect of the COVID-19 vaccines, especially in the ensuing waves of infections dominated by variants. METHODS: We searched PubMed, Embase and Web of Science from inception to July 22, 2021. Observational studies that examined the effectiveness and safety of SARS-CoV-2 vaccines among people vaccinated were included. Random-effects or fixed-effects models were used to estimate the pooled vaccine effectiveness (VE) and incidence rate of adverse events after vaccination, and their 95% confidence intervals (CI). RESULTS: A total of 58
2021-08-22
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Zheda Road 38, Hangzhou 310027, China.; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Zheda Road 38, Hangzhou 310027, China.; Life Sciences Institute, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, China.; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Zheda Road 38, Hangzhou 310027, China.; Life Sciences Institute, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, China.. Electronic address: liujz@zju.edu.cn.
Synthetic modified messenger RNA (mRNA) has manifested great potentials for therapeutic applications such as vaccines and gene therapies, with the recent mRNA vaccines for global pandemic COVID-19 (corona virus disease 2019) attracting the tremendous attention. The chemical modifications and delivery vehicles of synthetic mRNAs are the two key factors for their in vivo therapeutic applications. Chemical modifications like nucleoside methylation endow the synthetic mRNAs with high stability and reduced stimulation of innate immunity. The development of scalable production of synthetic mRNA and efficient mRNA formulation and delivery strategies in recent years have remarkably advanced the field. It is worth noticing that we had limited knowledge on the roles of mRNA modifications in the past. However, the last decade has witnessed not only new discoveries of several naturally occurring mRNA modifications but also substantial advances in understanding their roles on regulating gene
2021-07-25
Department of Economics, University of Birmingham, Birmingham, B15 2TT, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Haidian District, No. 38, Xueyuan Road, Beijing, 100191, China.; Center for Primary Care and Outcomes Research, School of Medicine, Center for Health Policy, Freeman Spogli Institute for International Studies, Stanford University, 450 Jane Stanford Way, Stanford, CA, 94305-2004, USA.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Haidian District, No. 38, Xueyuan Road, Beijing, 100191, China. jueliu@bjmu.edu.cn.; Institute for Global Health and Development, Peking University, No. 5 Yiheyuan Road, Haidian, Beijing, 100871, China. jueliu@bjmu.edu.cn.; National Health Commission Key Laboratory of Reproductive Health, Peking University, No. 38, Xueyuan Road, Haidian, Beijing, 100191, China. jueliu@bjmu.edu.cn.
BACKGROUND: Little attention has been paid to the comparison of COVID-19 pandemic responses and related factors in BRICS (Brazil, Russia, India, China, and South Africa) countries. We aimed at evaluating the association of daily new COVID-19 cases with socio-economic and demographic factors, health vulnerability, resources, and policy response in BRICS countries. METHODS: We conducted a cross-sectional study using data on the COVID-19 pandemic and other indicators of BRICS countries from February 26, 2020 to April 30, 2021. We compared COVID-19 epidemic in BRICS countries and analyzed related factors by log-linear Generalized Additive Model (GAM) models. RESULTS: In BRICS countries, India had the highest totally of confirmed cases with 18.76 million, followed by Brazil (14.45 million), Russia (4.81 million), and South Africa (1.58 million), while China (0.10 million) had the lowest figure. South Africa had the lowest rate of administered vaccine doses (0.18 million) among BRICS
2021-06-14
Cardiology Division, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.; Cardiology Division, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.; Weill Cornell Medical College, New York, NY, USA.; Cardiology Division, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.; Weill Cornell Medical College, New York, NY, USA.; Cardiology Division, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA. guptad@mskcc.org.; Weill Cornell Medical College, New York, NY, USA. guptad@mskcc.org.
Cardio-oncology is a field dedicated to the prevention, diagnosis, and management of cardiovascular disease in cancer patients before, during, and after cancer therapy. It is an emerging field with limited opportunities for structured education and training. In the year 2021, we cannot define the requirements of cardio-oncology training without acknowledging the impact of the global coronavirus disease 19 (COVID-19) pandemic. While this pandemic poses significant health risks to patients with cancer and cardiovascular disease as well as the providers who care for them, it also allows novel opportunities for the nascent field of cardio-oncology to readily adapt. In this article, we detail how the COVID-19 pandemic has impacted all aspects of cardio-oncology training, how programs and trainees can adapt to these challenges, and how lessons learned from the COVID-19 era can continue to positively impact cardio-oncology training for the foreseeable future.
2021-01-19
School of Medicine, Macau University of Science and Technology, Macau, China.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Tongzhou District, Beijing, China.; Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Tongzhou District, Beijing, China.
BACKGROUND: The COVID-19 pandemic has resulted in changes to normal life and disrupted social and economic function worldwide. However, little is known about the impact of social media use, unhealthy lifestyles, and the risk of miscarriage among pregnant women during the COVID-19 pandemic. OBJECTIVE: This study aims to assess the association between social media use, unhealthy lifestyles, and the risk of miscarriage among pregnant women in the early stage of the COVID-19 pandemic in China. METHODS: In this prospective cohort study, 456 singleton pregnant women in mainland China were recruited during January and February 2020. Sociodemographic characteristics, history of previous health, social media use, and current lifestyles were collected at baseline, and we followed up about the occurrence of miscarriage. Log-binomial regression models were used to estimate the risk ratios (RRs) of miscarriage for women with different exposures to COVID-19-specific information. RESULTS: Among all