2021-11-21

GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy. alberto.cereda@email.it.; Cardiovascular Department, ASST Santi Paolo e Carlo, Milan, Italy. alberto.cereda@email.it.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; Ospedale di Cremona, Cremona, Italy.; Ospedale di Cremona, Cremona, Italy.; Centro Cardiologico Monzino IRCCS, Milan, Italy.; Centro Cardiologico Monzino IRCCS, Milan, Italy.; Ospedale Maggiore, Bologna, Italy.; Ospedale Maggiore, Bologna, Italy.; San Gerardo Hospital, Monza, Italy.; San Gerardo Hospital, Monza, Italy.; ASST Bolognini Hospital, Bergamo Est, Seriate, Italy.; ASST Bolognini Hospital, Bergamo Est, Seriate, Italy.; Parma University Hospital, Parma, Italy.; Parma University Hospital, Parma, Italy.; San Giovanni Bosco Hospital, ASL Citta di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Citta di Torino, Turin, Italy.; Università degli Studi di Roma "Tor Vergata", Roma, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.

Recent clinical and demographical studies on COVID-19 patients have demonstrated that men experience worse outcomes than women. However, in most cases, the data were not stratified according to gender, limiting the understanding of the real impact of gender on outcomes. This study aimed to evaluate the disaggregated in-hospital outcomes and explore the possible interactions between gender and cardiovascular calcifications. Data was derived from the sCORE-COVID-19 registry, an Italian multicentre registry that enrolled COVID-19 patients who had undergone a chest computer tomography scan on admission. A total of 1683 hospitalized patients (mean age 67±14 years) were included. Men had a higher prevalence of cardiovascular comorbidities, a higher pneumonia extension, more coronary calcifications (63% vs.50.9%, p<0.001), and a higher coronary calcium score (391±847 vs. 171±479 mm(3), p<0.001). Men experienced a significantly higher mortality rate (24.4% vs. 17%, p=0.001), but the death

2021-09-01

GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy. Electronic address: giannini_fra@yahoo.it.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Ospedale di Cremona, Cremona, Italy.; Ospedale di Cremona, Cremona, Italy.; Ospedale di Cremona, Cremona, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Ospedale Maggiore, Bologna, Italy.; Ospedale Maggiore, Bologna, Italy.; Ospedale Maggiore, Bologna, Italy.; San Gerardo Hospital, Monza, Italy.; San Gerardo Hospital, Monza, Italy.; San Gerardo Hospital, Monza, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; Parma University Hospital, Parma, Italy.; Parma University Hospital, Parma, Italy.; Parma University Hospital, Parma, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy; Casa di Cura Villa dei Pini, Civitanova Marche, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Casa di Cura Villa dei Pini, Civitanova Marche, Italy.; ICC Istituto Clinico Casalpalocco, Rome, Italy.; ICC Istituto Clinico Casalpalocco, Rome, Italy.; San L. Mandic Hospital, Merate, Italy.; San L. Mandic Hospital, Merate, Italy.; San L. Mandic Hospital, Merate, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; IRCCS San Raffaele Scientific Institute, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.

BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread worldwide determining dramatic impacts on healthcare systems. Early identification of high-risk parameters is required in order to provide the best therapeutic approach. Coronary, thoracic aorta and aortic valve calcium can be measured from a non-gated chest computer tomography (CT) and are validated predictors of cardiovascular events and all-cause mortality. However, their prognostic role in acute systemic inflammatory diseases, such as COVID-19, has not been investigated. OBJECTIVES: The aim was to evaluate the association of coronary artery calcium and total thoracic calcium on in-hospital mortality in COVID-19 patients. METHODS: 1093 consecutive patients from 16 Italian hospitals with a positive swab for COVID-19 and an admission chest CT for pneumonia severity assessment were included. At CT, coronary, aortic valve and thoracic aorta calcium were qualitatively and quantitatively evaluated separately and combined together

2021-07-07

Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; Division of Cardiology, Città Della Scienza e Della Salute, Dipartimento di Scienze Mediche University of Turin, Turin, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; Ospedale di Cremona, Cremona, Italy.; Ospedale di Cremona, Cremona, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Ospedale Maggiore, Bologna, Italy.; Ospedale Maggiore, Bologna, Italy.; San Gerardo Hospital, Monza, Italy.; San Gerardo Hospital, Monza, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; Parma University Hospital, Parma, Italy.; Parma University Hospital, Parma, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San L. Mandic Hospital, Merate, Italy.; San L. Mandic Hospital, Merate, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy. Electronic address: giannini_fra@yahoo.it.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.

0), (c) "No CAD" (CAC = 0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). RESULTS: Amongst 1625 patients (male 67.2%, median age 69">BACKGROUND AND AIMS: The potential impact of coronary atherosclerosis, as detected by coronary artery calcium, on clinical outcomes in COVID-19 patients remains unsettled. We aimed to evaluate the prognostic impact of clinical and subclinical coronary artery disease (CAD), as assessed by coronary artery calcium score (CAC), in a large, unselected population of hospitalized COVID-19 patients undergoing non-gated chest computed tomography (CT) for clinical practice. METHODS: SARS-CoV 2 positive patients from the multicenter (16 Italian hospitals), retrospective observational SCORE COVID-19 (calcium score for COVID-19 Risk Evaluation) registry were stratified in three groups: (a) "clinical CAD" (prior revascularization history), (b) "subclinical CAD" (CAC >0), (c) "No CAD" (CAC = 0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). RESULTS: Amongst 1625 patients (male 67.2%, median age 69