2021-04-07

Population Wellbeing and Environment Research Lab (PowerLab), Faculty of Arts, Social Sciences and Humanities, School of Health and Society, University of Wollongong, Wollongong, NSW 2522, Australia.; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.; School of Population Medicine and Public Health, Peking Union Medical College, The Chinese Academy of Medical Sciences, Dongcheng District, Beijing 100730, China.; National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.; Menzies Centre for Health Policy, University of Sydney, Sydney, NSW 2006, Australia.; Population Wellbeing and Environment Research Lab (PowerLab), Faculty of Arts, Social Sciences and Humanities, School of Health and Society, University of Wollongong, Wollongong, NSW 2522, Australia.; National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.; Menzies Centre for Health Policy, University of Sydney, Sydney, NSW 2006, Australia.; Faculty of Medicine, School of Population Health, UNSW, Sydney, NSW 2052, Australia.

We hypothesized that visits to green and blue spaces may have enabled respite, connection and exercise during the COVID-19 pandemic, but such benefits might have been inequitably distributed due to differences in financial difficulties, opportunities to work from home, and localized restrictions in spatial mobility generated by 'lockdowns'. A nationally representative online and telephone survey conducted in 12-26 October on the Social Research Centre's Life in Australia(TM) panel (aged ≥ 18 y, 78.8% response, N = 3043) asked about access, visitation, and felt benefits from green and/or blue spaces. Increasing financial difficulty was associated with less time in and fewer visits to green and/or blue spaces, as well as fewer different types visited. Financial difficulty was also associated with feelings that visits to green and/or blue space had less benefit for maintaining social connection. Working from home was associated with more frequent and longer visitation to green and/or

2021-02-11

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Department of Pathology, Anhui Medical University, Hefei, China.; Zhejiang University, Hangzhou, China.; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Objective: The prognosis of mild and severe patients has prominent differences during the prevalence of COVID-19, and it will be significant to identify patients' potential risk of progressing to severe cases according to their first clinical presentations. Therefore, we aim to review the clinical symptoms of the COVID-19 epidemic systematically. Methods:We searched PubMed, Embase, Web of Science, and CNKI (Chinese Database) for studies about the clinical features of COVID-19 in China from March 18 to April 18. Then we used REVMAN to conduct a meta-analysis. Results: After screening, 20 articles including 3,326 COVID-19 confirmed cases were selected from 142 articles we retrieved at the beginning of our research. We divided all the cases into a severe group (including severe and critically severe patients) and a mild group according to the "Diagnosis and Treatment Protocol for Novel Coronavirus Infection-Induced Pneumonia" version 4 (trial). Of all the initial symptoms (including

2021-04-12

Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi Province, People's Republic of China.; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China.; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China.; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.; DME Center, Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, People's Republic of China.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi Province, People's Republic of China.; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. mailzhangyong@126.com.; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China. zhangliming@bjcyh.com.; Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi Province, People's Republic of China. liuzhengwen113@xjtu.edu.cn.

BACKGROUND: Risk scores are needed to predict the risk of death in severe coronavirus disease 2019 (COVID-19) patients in the context of rapid disease progression. METHODS: Using data from China (training dataset, n = 96), prediction models were developed by logistic regression and then risk scores were established. Leave-one-out cross validation was used for internal validation and data from Iran (test dataset, n = 43) was used for external validation. RESULTS: A NSL model (area under the curve (AUC) 0.932) and a NL model (AUC 0.903) were developed based on neutrophil percentage and lactate dehydrogenase with and without oxygen saturation (SaO(2)) using the training dataset. AUCs of the NSL and NL models in the test dataset were 0.910 and 0.871, respectively. The risk scoring systems corresponding to these two models were established. The AUCs of the NSL and NL scores in the training dataset were 0.928 and 0.901, respectively. At the optimal cut-off value of NSL score, the

2020-03-11

Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

2020-03-11

Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Occupational & Environmental Health, School of Public Health,; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

College of Medical Information Engineering, Chengdu University of Traditional; Chinese Medicine, Chengdu 611137, China; Clinical Research Center, Zhujiang Hospital, Southern Medical University,; Guangzhou 510280, China; School of Public Health, Chengdu Medical College, Chengdu 610500, China;; School of Public Health, Peking University, Beijing 100191, China;; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong,; China; School of Nursing, Hong Kong Polytechnic University, Hong Kong, China;; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou; University, Lanzhou 730000, China; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;; School of Public Health, Chengdu Medical College, Chengdu 610500, China;; School of Public Health, Lanzhou University, Lanzhou 730000, China;; Department of Respiratory, Ministry of Education Key Laboratory of Child; Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China; Department of Respiratory, Ministry of Education Key Laboratory of Child; Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China; College of Medical Information Engineering, Chengdu University of Traditional; Chinese Medicine, Chengdu 611137, China; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou; University, Lanzhou 730000, China; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong,; China;

Background: An ongoing outbreak of pneumonia caused by a novel coronavirus [severe acute respiratory syndrome coronavirus (SARS-CoV)-2], named COVID-19, hit a major city of China, Wuhan in December 2019 and subsequently spread to other provinces/regions of China and overseas. Several studies have been done to estimate the basic reproduction number in the early phase of this outbreak, yet there are no reliable estimates of case fatality rate (CFR) for COVID-19 to date. Methods: In this study, we used a purely data-driven statistical method to estimate the CFR in the early phase of the COVID-19 outbreak. Daily numbers of laboratory-confirmed COVID-19 cases and deaths were collected from January 10 to February 3, 2020 and divided into three clusters: Wuhan city, other cities of Hubei province, and other provinces of mainland China. Simple linear regression model was applied to estimate the CFR from each cluster. Results: We

College of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, China; School of Public Health, Chengdu Medical College, Chengdu, China.; College of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Public Health, Lanzhou University, Lanzhou, China.; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China; WHO Collaborating Centre for Guideline Implementation and Knowledge Translation, Lanzhou, China; GIN (Guidelines International Network) Asia, Lanzhou, China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou, China.; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.; School of Public Health, Lanzhou University, Lanzhou, China.; School of Public Health, Chengdu Medical College, Chengdu, China.; School of Clinical Medicine, Chengdu Medical College, Chengdu, China.; School of Public Health, Chengdu Medical College, Chengdu, China.; The Second School of Clinical Medicine, Chongqing Medical University, Chongqing, China.; Department of Pediatric, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.; School of Pharmacy, Chengdu Medical College, Chengdu, China.; Department of Emergency Medicine, The General Hospital of Western Theater Command of PLA, Chengdu, China.; College of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Public Health, Chengdu Medical College, Chengdu, China.CN - COVID-19 Evidence and Recommendations Working Group

BACKGROUND: Corona virus disease 2019 (COVID-19) showed a significant difference in case fatality rate between different regions at the early stage of the epidemic. In addition to the well-known factors such as age structure, detection efficiency, and race, there was also a possibility that medical resource shortage caused the increase of the case fatality rate in some regions. METHODS: Medline, Cochrane Library, Embase, Web of Science, CBM, CNKI, and Wan fang of identified articles were searched through 29 June 2020. Cohort studies and case series with duration information on COVID-19 patients were included. Two independent reviewers extracted the data using a standardized data collection form and assessed the risk of bias. Data were synthesized through description and analysis methods including a meta-analysis. RESULTS: A total of 109 articles were retrieved. The time interval from onset to the first medical visit of COVID-19 patients in China was 3.38±1.55 days (corresponding

College of Medical Information Engineering, Chengdu University of Traditional; Chinese Medicine, Chengdu 611137, China; Clinical Research Center, Zhujiang Hospital, Southern Medical University,; Guangzhou 510280, China; School of Public Health, Chengdu Medical College, Chengdu 610500, China;; School of Public Health, Peking University, Beijing 100191, China;; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong,; China; School of Nursing, Hong Kong Polytechnic University, Hong Kong, China;; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou; University, Lanzhou 730000, China; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;; School of Public Health, Chengdu Medical College, Chengdu 610500, China;; School of Public Health, Lanzhou University, Lanzhou 730000, China;; Department of Respiratory, Ministry of Education Key Laboratory of Child; Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China; Department of Respiratory, Ministry of Education Key Laboratory of Child; Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China; College of Medical Information Engineering, Chengdu University of Traditional; Chinese Medicine, Chengdu 611137, China; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou; University, Lanzhou 730000, China; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong,; China;

Background: An ongoing outbreak of pneumonia caused by a novel coronavirus [severe acute respiratory syndrome coronavirus (SARS-CoV)-2], named COVID-19, hit a major city of China, Wuhan in December 2019 and subsequently spread to other provinces/regions of China and overseas. Several studies have been done to estimate the basic reproduction number in the early phase of this outbreak, yet there are no reliable estimates of case fatality rate (CFR) for COVID-19 to date. Methods: In this study, we used a purely data-driven statistical method to estimate the CFR in the early phase of the COVID-19 outbreak. Daily numbers of laboratory-confirmed COVID-19 cases and deaths were collected from January 10 to February 3, 2020 and divided into three clusters: Wuhan city, other cities of Hubei province, and other provinces of mainland China. Simple linear regression model was applied to estimate the CFR from each cluster. Results: We

2021-10-03

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China. ljli@zju.edu.cn.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City, 310003, China. zdyxyxkj@zju.edu.cn.

BACKGROUND: Knowledge about the 1-year outcome of COVID-19 is limited. The aim of this study was to follow-up and evaluate lung abnormalities on serial computed tomography (CT) scans in patients with COVID-19 after hospital discharge. METHODS: A prospective cohort study of patients with COVID-19 from the First Affiliated Hospital, Zhejiang University School of Medicine was conducted, with assessments of chest CT during hospitalization and at 2 weeks, 1 month, 3 months, 6 months, and 1 year after hospital discharge. Risk factors of residual CT opacities and the influence of residual CT abnormalities on pulmonary functions at 1 year were also evaluated. RESULTS: A total of 41 patients were followed in this study. Gradual recovery after hospital discharge was confirmed by the serial CT scores. Around 47% of the patients showed residual aberration on pulmonary CT with a median CT score of 0 (interquartile range (IQR) of 0-2) at 1 year after discharge, with ground-glass opacity (GGO) with

2021-10-05

Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Pathology, NYU Langone Medical Center, New York, New York, USA.; Department of Epidemiology and Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei, China.; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Laboratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Computer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.; Department of Medical Administration, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R. China.

The 1-year mortality and health consequences of COVID-19 in cancer patients are relatively underexplored. In this multicenter cohort study, 166 COVID-19 patients with cancer were compared with 498 non-cancer COVID-19 patients and 498 non-COVID cancer patients. The 1-year all-cause mortality and hospital mortality rates in Cancer COVID-19 Cohort (30% and 20%) were significantly higher than those in COVID-19 Cohort (9% and 8%, both P < .001) and Cancer Cohort (16% and 2%, both P < 0.001). The 12-month all-cause post-discharge mortality rate in survival discharged Cancer COVID-19 Cohort (8%) was higher than that in COVID-19 Cohort (0.4%, P < .001) but similar to that in Cancer Cohort (15%, P = .084). The incidence of sequelae in Cancer COVID-19 Cohort (23%, 26/114) is similar to that in COVID-19 Cohort (30%, 130/432, P = .13). The 1-year all-cause mortality was high among patients with hematologic malignancies (59%), followed by those who have nasopharyngeal, brain, and skin tumors (45%