2021-09-01

GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy. Electronic address: giannini_fra@yahoo.it.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Ospedale di Cremona, Cremona, Italy.; Ospedale di Cremona, Cremona, Italy.; Ospedale di Cremona, Cremona, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Ospedale Maggiore, Bologna, Italy.; Ospedale Maggiore, Bologna, Italy.; Ospedale Maggiore, Bologna, Italy.; San Gerardo Hospital, Monza, Italy.; San Gerardo Hospital, Monza, Italy.; San Gerardo Hospital, Monza, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; Parma University Hospital, Parma, Italy.; Parma University Hospital, Parma, Italy.; Parma University Hospital, Parma, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy; Casa di Cura Villa dei Pini, Civitanova Marche, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; Casa di Cura Villa dei Pini, Civitanova Marche, Italy.; ICC Istituto Clinico Casalpalocco, Rome, Italy.; ICC Istituto Clinico Casalpalocco, Rome, Italy.; San L. Mandic Hospital, Merate, Italy.; San L. Mandic Hospital, Merate, Italy.; San L. Mandic Hospital, Merate, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; IRCCS San Raffaele Scientific Institute, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.

BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread worldwide determining dramatic impacts on healthcare systems. Early identification of high-risk parameters is required in order to provide the best therapeutic approach. Coronary, thoracic aorta and aortic valve calcium can be measured from a non-gated chest computer tomography (CT) and are validated predictors of cardiovascular events and all-cause mortality. However, their prognostic role in acute systemic inflammatory diseases, such as COVID-19, has not been investigated. OBJECTIVES: The aim was to evaluate the association of coronary artery calcium and total thoracic calcium on in-hospital mortality in COVID-19 patients. METHODS: 1093 consecutive patients from 16 Italian hospitals with a positive swab for COVID-19 and an admission chest CT for pneumonia severity assessment were included. At CT, coronary, aortic valve and thoracic aorta calcium were qualitatively and quantitatively evaluated separately and combined together

2021-07-07

Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; Division of Cardiology, Città Della Scienza e Della Salute, Dipartimento di Scienze Mediche University of Turin, Turin, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; Guglielmo da Saliceto Hospital, Piacenza, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; Ospedale di Cremona, Cremona, Italy.; Ospedale di Cremona, Cremona, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Centro Cardiologico Monzino IRCCS, Milano, Italy.; Ospedale Maggiore, Bologna, Italy.; Ospedale Maggiore, Bologna, Italy.; San Gerardo Hospital, Monza, Italy.; San Gerardo Hospital, Monza, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; ASST Bolognini Hospital, Bergamo Est, Italy.; Parma University Hospital, Parma, Italy.; Parma University Hospital, Parma, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.; San L. Mandic Hospital, Merate, Italy.; San L. Mandic Hospital, Merate, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Papa Giovanni XXIII, Bergamo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; ASST Valtellina and Alto Lario, "Eugenio Morelli Hospital", Sondalo, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.; IRCCS San Raffaele Scientific Institute, Italy; Vita-Salute San Raffaele University, Italy.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy. Electronic address: giannini_fra@yahoo.it.; GVM Care & Research Maria Cecilia Hospital Cotignola, Italy.

0), (c) "No CAD" (CAC = 0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). RESULTS: Amongst 1625 patients (male 67.2%, median age 69">BACKGROUND AND AIMS: The potential impact of coronary atherosclerosis, as detected by coronary artery calcium, on clinical outcomes in COVID-19 patients remains unsettled. We aimed to evaluate the prognostic impact of clinical and subclinical coronary artery disease (CAD), as assessed by coronary artery calcium score (CAC), in a large, unselected population of hospitalized COVID-19 patients undergoing non-gated chest computed tomography (CT) for clinical practice. METHODS: SARS-CoV 2 positive patients from the multicenter (16 Italian hospitals), retrospective observational SCORE COVID-19 (calcium score for COVID-19 Risk Evaluation) registry were stratified in three groups: (a) "clinical CAD" (prior revascularization history), (b) "subclinical CAD" (CAC >0), (c) "No CAD" (CAC = 0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). RESULTS: Amongst 1625 patients (male 67.2%, median age 69

2021-09-07

Division of Cardiology, Azienda Ospedaliero-Universitaria Maggiore della Carità, Università del Piemonte Orientale, Italy. Electronic address: giuseppe.deluca@med.uniupo.it.; Catholic University of Leuven, Leuven, Belgium.; Department of Cardiology, Medical Center Ljubljana, Slovenia.; Division of Cardiology, Odense Universitets Hospital, Odense, Denmark.; University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, Skopje, Macedonia.; Clinic Emergency Hospital of Bucharest, Romania.; Division of Cardiology, Bristol Heart Institute, University Hospitals Bristol NHSFT & University of Bristol, Bristol, UK.; Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, Spain.; Division of Cardiology,State Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.; Division of Cardiology, Medical University of Silezia, Katowice, Poland.; Division of Cardiology, University Hospital of Wales, Cardiff, UK.; Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, Enschede, the Netherlands.; Division of Cardiology, University Hospital, Dijon, France.; Division of Cardiology, Amphia Hospital, Breda, the Netherlands.; Division of Cardiology, Ospedale del Mare, Napoli, Italy.; Division of Cardiology, Ospedale Santa Maria Goretti Latina, Italy.; Division of Cardiology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.; Division of Cardiology, St Antonius Hospital, Nieuwegein, the Netherlands.; Division of Cardiology, Helsinki University Central Hospital, Finland.; Division of Cardiology, Northwest Clinics Alkmaar, the Netherlands.; Division of Cardiology, Division of Cardiology, Ospedali Riuniti, Reggio Calabria, Italy.; Division of Cardiology, Ospedale Maggiore Bologna, Italy.; University Hospital Brno, Medical Faculty of Masaryk University Brno, Czech Republic.; H. Universitario y Politécnico La Fe, Valencia, Spain.; John Radcliffe Hospital, Oxford, UK.; Cardiology Unit, Virgen de la Victoria University Hospital; IBIMA, Málaga, Spain. CIBERCV.; Division of Cardiology, Clinica Villa dei Fiori, Acerra, Italy.; Ospedale Santa Maria della Misericordia, Perugia, Italy.; Hospital Germans Triasi Pujol, Badalona, Spain.; Division of Cardiology, Ospedale "Sant'Anna", Ferrara, Italy.; Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands.; Mastricht University Medical Center, the Netherlands.; University Hospital Prague, Czech Republic.; Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, Patras, Greece.; University Hospital Munich, Ludwig-Maximilians University, Munich, Germany.; Interventional Cardiology Unit, Azienda Ospedaliero Universitaria "Ospedali Riuniti", Ancona, Italy.; Complexo Hospetaliero Universitario La Coruna, La Coruna, Spain.; Center for Cardiovascular Diseases, Ohrid, Macedonia.; Center Hospitalier Universitaire de Poitiers, Poitiers, University Hospital, Poitiers, France.; Division of Cardiology, Ospedale Civico Arnas, Palermo, Italy.; AUSL-IRCCS Reggio Emilia, Italy.; Central Hospital of Medical University of Lodz, Poland.; Division of Cardiology, Ospedale "Santa Maria della Misericordia", Udine, Italy.; Division of Cardiology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro, Italy.; University Hospital Birmingham, Birmingham, UK.; Ospedale Santa Chiara di Trento, Italy.; Division of Cardiology, Ospedale San Giovanni di Dio e Ruggid'Aragona, Salerno, Italy.; Azienda Ospedaliero - Universitaria Ospedali Riuniti Trieste, Italy.; Division of Cardiology, Medical University of Silezia, Katowice, Poland; Division of Cardiology, Ospedale "F. Spaziani", Frosinone, Italy.; Division of Cardiology, Hospital Puerta de Hierro Majadahonda, Spain.; Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, France.; Division of Cardiology, Ospedale "G Moscati", Aversa, Italy.; Division of Cardiology, Complejo Hospitalario de Toledo, Toledo, Spain.; Division of Cardiology, Hospital Clinico Universitario de Valencia, Spain.; Division of Cardiology, Ospedale "S. Maurizio", Bolzano, Italy.; Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Italy.; Division of Cardiology, Hospital de Santa Cruz, CHLO, Carnaxide, Portugal.; Division of Cardiology, Jessa Ziekenhuis, Hasselt, Belgium.; Division of Cardiology, Ziekenhuis Netwerk Antwerpen (ZNA) Middelheim, Antwerp, Belgium.; Division of Cardiology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.; Division of Cardiology, Oulu University Hospital, Finland.; Division of Cardiology, Juan Ramon Jimenez Hospital, Huelva, Spain.; Division of Cardiology, UMC Utrecht, the Netherlands.; Division of Cardiology, Heart Centre Turku, Finland.; Division of Cardiology, Ospedale Santa Maria delle Grazie, Pozzuoli, Italy.; Division of Cardiology, CHU Timone, Marseille, France; Faculté de Médecine, Aix-Marseille Université, Marseille, France.; Division of Cardiology, Hospital Cabueñes, Gijon, Spain.; Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, Germany.; 2(nd)Division of Cardiology, Attikon University Hospital, Athens, Greece.; Division of Cardiology, Hospital la Paz, Madrid, Spain.; Division of Cardiology, Ospedale "A. Manzoni", Lecco, Italy.; Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, France.; Division of Cardiology, Hospital Puerta del Mar, Cadiz, Spain.; Division of Cardiology, Ospedale "F. Spaziani", Frosinone, Italy.; Division of Cardiology, Jessa Ziekenhuis, Hasselt, Belgium.; Division of Cardiology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.; Division of Cardiology, St Antonius Hospital, Nieuwegein, the Netherlands.; Division of Cardiology, Ospedale del Mare, Napoli, Italy.; Azienda Ospedaliero-Universitaria Sassari, Italy.; Division of Cardiology, Hopital Erasme, Universitè Libre de Bruxelles, Belgium.; Division of Cardiology, Ospedale degli Infermi, ASL, Biella, Italy.

BACKGROUND AND AIMS: SARS-Cov-2 predisposes patients to thrombotic complications, due to excessive inflammation, endothelial dysfunction, platelet activation, and coagulation/fibrinolysis disturbances. The aim of the present study was to evaluate clinical characteristics and prognostic impact of SARS-CoV-2 positivity among STEMI patients undergoing primary percutaneous coronary intervention (PPCI). METHODS: We selected SARS-CoV-2 positive patients included in the ISACS-STEMI COVID-19, a retrospective multicenter European registry including 6609 STEMI patients treated with PPCI from March 1st until April 30th, in 2019 and 2020. As a reference group, we randomly sampled 5 SARS-Cov-2 negative patients per each SARS-CoV-2 positive patient, individually matched for age, sex, and hospital/geographic area. Study endpoints were in-hospital mortality, definite stent thrombosis, heart failure. RESULTS: Our population is represented by 62 positive SARS-CoV-2 positive patients who were compared