2021-09-28

Zydus Hospital, Ahmedabad, Gujarat, India.; Department of ENT, GCS Medical College, Ahmedabad, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Department of Neurology, Ramkrishna Care Hospitals, Raipur, India.; Department of Neurology, Max Hospital, New Delhi, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Department of Neurology, Ramkrishna Care Hospitals, Raipur, India.; Zydus Hospital, Ahmedabad, Gujarat, India.; Department of Neurology, Ramkrishna Care Hospitals, Raipur, India.; Department of Neurology, Ramkrishna Care Hospitals, Raipur, India.; Department of Neurology, Ramkrishna Care Hospitals, Raipur, India.; Department of Neurology, Ramkrishna Care Hospitals, Raipur, India.; BJ Medical College and Civil Hospital, Ahmedabad, India.; Division of Neurology, Department of Medicine, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Zydus Hospital, Ahmedabad, Gujarat, India.; Division of Neurology, Department of Medicine, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Division of Neurology, Department of Medicine, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

IMPORTANCE: Coronavirus disease (COVID-19) causes an immunosuppressed state and increases risk of secondary infections like mucormycosis. We evaluated clinical features, predisposing factors, diagnosis and outcomes for mucormycosis among patients with COVID-19 infection. METHODS: This prospective, observational, multi-centre study included 47 consecutive patients with mucormycosis, diagnosed during their course of COVID-19 illness, between January 3 and March 27, 2021. Data regarding demography, underlying medical conditions, COVID-19 illness and treatment were collected. Clinical presentations of mucormycosis, imaging and biochemical characteristics and outcome were recorded. RESULTS: Of the 2567 COVID-19 patients admitted to 3 tertiary centres, 47 (1.8%) were diagnosed with mucormycosis. Mean age was 55 ± 12.8years, and majority suffered from diabetes mellitus (n = 36, 76.6%). Most were not COVID-19 vaccinated (n = 31, 66.0%) and majority (n = 43, 91.5%) had developed

Pulmonary Department, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, 57010 Thessaloniki, Greece.; 1st Department of Critical Care and Pulmonary Medicine, Evaggelismos Hospital, National and Kapodistrian University of Athens, 10679 Athens, Greece.; 1st Department of Critical Care and Pulmonary Medicine, Evaggelismos Hospital, National and Kapodistrian University of Athens, 10679 Athens, Greece.; Intensive Care Unit, General Hospital of Trikala, 42100 Trikala, Greece.; Department of Respiratory Medicine, Medical School, Democritus University of Thrace, 67100 Alexandroupolis, Greece.

The coronavirus disease 2019 (COVID-19) pandemic, related to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a worldwide sudden and substantial burden in public health due to an enormous increase in hospitalizations for pneumonia with the multiorgan disease. Treatment for individuals with COVID-19 includes best practices for supportive management of acute hypoxic respiratory failure. Emerging data indicate that dexamethasone therapy reduces 28-day mortality in patients requiring supplemental oxygen compared with usual care, and ongoing trials are testing the efficacy of antiviral therapies, immune modulators and anticoagulants in the prevention of disease progression and complications, while monoclonal antibodies and hyperimmune globulin may provide additional preventive strategies. Consensus suggestions can standardize care, thereby improving outcomes and facilitating future research. This review discusses current evidence regarding the