共检索4条数据Total:4
2021-06-03
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.; Department of Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, China.; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
BACKGROUND: Knowledge of the impact of COVID-19 on the mental health of college students remains limited. Our aim is to investigate the prevalence of anxiety and explore the potential risk and protective factors of anxiety. METHODS: A cross-sectional survey was adopted and a total of 24,678 college students were included from Zhengzhou, Henan Province, China, during February, 2020. Anxiety was assessed by using the Generalized Anxiety Disorder tool (GAD-7). Multiple logistic regression models were established for exploring potential factors of anxiety. RESULTS: The overall prevalence of anxiety was 7.3%. After adjusting for potential confounders, sex, place of residence, worried level, fear level, cognitive levels, and behavior status were found to be associated with anxiety (p < 0.05). Students with positive preventive behaviors showed a protective effect against the anxiety symptoms compared to those with negative preventive behaviors. In contrast to the high-cognition category
2021-11-08
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China.; Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao-Tong University, Shanghai, China.; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Department of Laboratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.; Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao-Tong University, Shanghai, China.; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China.; Department of Laboratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.; Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China.; Department of Infectious Disease, Research Laboratory of Clinical Virology, Ruijin Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.; Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. luhongzhou@fudan.edu.cn.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China. zhujiang@shsmu.edu.cn.; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China. zhujiang@shsmu.edu.cn.; Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao-Tong University, Shanghai, China. jmqu0906@163.com.; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China. jmqu0906@163.com.; National Research Center for Translational Medicine at Shanghai, Shanghai, China. jmqu0906@163.com.
Increasing numbers of SARS-CoV-2-positive (SARS-CoV-2(pos)) subjects are detected at silent SARS-CoV-2 infection stage (SSIS). Yet, SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease. Here, we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-CoV-2(pos) subjects, 47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects, and interrogated them with combined assays of 44-plex CyTOF, RNA-seq and Olink. Notably, both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations, while certain parameters including more severely decreased frequencies of CD107a(low) classical monocytes, intermediate monocytes, non-classical monocytes and CD62L(hi) CD8(+) T(naïve) cells, reduced plasma STC1 level but an increased frequency of CD4(+) NKT cells combined to distinguish the latter.
2021-10-03
National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; School of Medicine, Shanghai University, Shanghai, 200444, China.; Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, 102629, China.; Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences, Beijing, 100071, China.; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100871, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; Beijing Institute of Biotechnology, Beijing, 100871, China.; Beijing Institute of Biotechnology, Beijing, 100871, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100871, China.; Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences, Beijing, 100071, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.; School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.; School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.; Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences, Beijing, 100071, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Jiangsu Pacific Meinuoke Biopharmceutical Co. Ltd, Changzhou, 213022, China.; Jiangsu Pacific Meinuoke Biopharmceutical Co. Ltd, Changzhou, 213022, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.; Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China. hjbian@fmmu.edu.cn.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. zhuping@fmmu.edu.cn.; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China. znchen@fmmu.edu.cn.
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants. Here, we identified CD147 as a universal receptor for SARS-CoV-2 and its variants. Meanwhile, Meplazeumab, a humanized anti-CD147 antibody, could block cellular entry of SARS-CoV-2 and its variants-alpha, beta, gamma, and delta, with inhibition rates of 68.7, 75.7, 52.1, 52.1, and 62.3% at 60 μg/ml, respectively. Furthermore, humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants, alpha and beta. When infected, these mice developed exudative alveolar pneumonia, featured by immune responses involving alveoli-infiltrated macrophages, neutrophils, and lymphocytes and activation of IL-17 signaling pathway. Mechanistically, we proposed that severe COVID-19-related cytokine
2021-05-30
National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China. hjbian@fmmu.edu.cn.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; College of Military Preventive Medicine, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Pharmaceutics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; Department of Pathology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.; College of Military Preventive Medicine, Fourth Military Medical University, Xi'an, China.; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.; Department of Foreign Languages, Fourth Military Medical University, Xi'an, China.; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China. znchen@fmmu.edu.cn.; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. zhuping@fmmu.edu.cn.
Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication. Meplazumab is a humanized anti-CD147 IgG(2) monoclonal antibody, which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019 (COVID-19) patients. Here, we conducted a randomized, double-blinded, placebo-controlled phase 1 trial to evaluate the safety, tolerability, and pharmacokinetics of meplazumab in healthy subjects, and an open-labeled, concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients. In phase 1 study, 59 subjects were enrolled and assigned to eight cohorts, and no serious treatment-emergent adverse event (TEAE) or TEAE grade ≥3 was observed. The serum and peripheral blood C(max) and area under the curve showed non-linear pharmacokinetic characteristics. No obvious relation between