2021-11-15

School of Medicine, West Virginia University, United States of America; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States of America.; School of Medicine, West Virginia University, United States of America; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States of America; West Virginia Clinical and Translational Science Institute, United States of America. Electronic address: shitiz.sriwastava@hsc.wvu.edu.

2021-10-26

Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; Army College of Medical Sciences, New Delhi, India.; University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; West Virginia Clinical and Translational Science Institute, Morgantown, West Virginia, USA.; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; West Virginia Clinical and Translational Science Institute, Morgantown, West Virginia, USA.

Novel coronavirus disease (COVID-19) first described in Wuhan, China in December 2019, has rapidly spread across the world and become a global public health emergency. Literature on the neurological manifestations of COVID-19 is limited. We report a 24-year-old male, who presented with vertigo, dysarthria, and bradyphrenia 3 weeks after being diagnosed with COVID-19 on nasopharyngeal reverse transcription polymerase chain reaction. The patient was diagnosed with acute cerebellitis based on magnetic resonance imaging features and showed improvement posttreatment with intravenous methylprednisone for 5 days. The scope of this article is to highlight the importance of early identification of neurological symptoms and timely management as the outcomes may be catastrophic.CI - © 2021 Wiley Periodicals LLC.

2021-03-24

Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA.; Department of Neurology, University of Missouri Healthcare, Columbia, MO, USA.; B.J. Medical College and Civil hospital, Ahmedabad, India.; Institute of Medicine, Kathmandu, Nepal.; Safdarjung Hospital, India.; Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA.; Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA.; Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA.; Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA; West Virginia Clinical Transitional Science, Morgantown, WV, USA. Electronic address: shitiz.sriwastava@hsc.wvu.edu.

OBJECTIVE: To report a unique case and literature review of post COVID-19 associated transverse myelitis and dysautonomia with abnormal MRI and CSF findings. BACKGROUND: Coronavirus disease have been reported to be associated with several neurological manifestations such as stroke, Guillain-Barré syndrome, meningoencephalitis amongst others. There are only few reported cases of transverse myelitis with the novel coronavirus (n-CoV-2) and only one reported case identifying dysautonomia in COVID-19 patient. Here, we identify a COVID-19 patient diagnosed with acute transverse myelitis in addition to dysautonomia following with complete resolution of symptoms. METHOD: A retrospective chart review of a patient diagnosed with post SARS-CoV-2 infection acute transverse myelitis and dysautonomia, and a review of literature of all the reported cases of transverse myelitis and COVID-19, from December 1st, 2019 till December 25th, 2020, was performed. CONCLUSION: To our knowledge, this is the

Army College of Medical Sciences, New Delhi 110010, India.; Department of Neurology, Wayne State University, Detroit, MI 48201, USA.; B.J. Medical College and Civil Hospital, Ahmedabad 380016, India.; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.; Kathmandu Medical College, Kathmandu 44600, Nepal.; Department of Biostatistics, West Virginia University, Morgantown, WV 26506, USA.; Department of Biostatistics, West Virginia University, Morgantown, WV 26506, USA.; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.; West Virginia Clinical and Translational Science Institute, Morgantown, WV 26506, USA.

BACKGROUND: The data on neurological manifestations in COVID-19 patients has been rapidly increasing throughout the pandemic. However, data on CNS and PNS inflammatory disorders in COVID-19 with respect to CSF, serum and neuroimaging markers is still lacking. METHODS: We screened all articles resulting from a search of PubMed, Google Scholar and Scopus, using the keywords "SARS-CoV-2 and neurological complication", "SARS-CoV-2 and CNS Complication" and "SARS-CoV-2 and PNS Complication" looking for transverse myelitis, vasculitis, acute disseminated encephalomyelitis, acute hemorrhagic necrotizing encephalitis (AHNE), cytotoxic lesion of the corpus callosum (CLOCC) and Guillain-Barré syndrome (GBS), published between 1 December 2019 to 15 July 2021. RESULTS: Of the included 106 CNS manifestations in our study, CNS inflammatory disorders included transverse myelitis (17, 14.7%), AHNE (12, 10.4%), ADEM (11, 9.5%), CLOCC/MERS (10, 8.6%) and vasculitis (4, 3.4%). Others were nonspecific

Institute of Nuclear Medicine and Allied Sciences, New Delhi 110054, India.; Institute of Medicine, Kathmandu P.O.BOX 1524, Nepal.; Safdarjung Hospital, New Delhi 110029, India.; Department of Biostatistics, West Virginia University, Morgantown, WV 26506, USA.; Department of Epidemiology, Fay W. Boozman, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Department of Neurology, University of Missouri Healthcare, Columbia, MO 65212, USA.; School of Medicine, West Virginia University, Morgantown, WV 26506, USA.; School of Medicine, West Virginia University, Morgantown, WV 26506, USA.; Department of Neuropsychiatry, Minia University, Minia 61519, Egypt.; Department of Neurology, Berkeley Medical Center, West Virginia University, Morgantown, WV 26506, USA.; Meditrina Institute of Medical Sciences, Nagpur, Maharashtra 440012, India.; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.; Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.; Department of Neurology, Wayne State University, Detroit, MI 48201, USA.

We performed a systematic literature review of neuroimaging, predominantly focusing on magnetic resonance imaging (MRI) findings associated with neurological manifestations of coronavirus disease-2019 (COVID-19). We screened articles from PubMed, Google Scholar and Scopus, looking for reports that would potentially have neuroimaging findings in patients with COVID-19. Data analysis was performed with patient-based data based on the availability of clinical characteristics and outcomes for each individual patient from the studies. Chi square and Wilcoxon rank-sum tests were used to report COVID-19 severity and outcomes based on neurological imaging indicators and pathophysiology. A total of 171 patients with COVID-19 having neurological complications, from 134 studies, were identified in our review. The most common neuroimaging finding was ischemic stroke (62, 36.2%) cases, followed by CNS inflammatory disorder (44, 25.7%), and hemorrhagic stroke (41, 24.0%). Around 51% of all the