2020-02-21

grid.9227.e0000000119573309CAS Key Laboratory of Pathogenic Microbiology and; Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 China grid.9227.e0000000119573309CAS Key Laboratory of Pathogenic Microbiology and; Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 China

2020-02-21

grid.9227.e0000000119573309CAS Key Laboratory of Pathogenic Microbiology and; Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 China grid.9227.e0000000119573309CAS Key Laboratory of Pathogenic Microbiology and; Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 China

2021-11-16

Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Cardiovascular Medicine, The University of Tokushima, Tokushima 770-8503, Japan.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social and economic activities, as well as public health. In most patients, the symptoms of COVID-19 are a high-grade fever and a dry cough, and spontaneously resolve within ten days. However, in severe cases, COVID-19 leads to atypical bilateral interstitial pneumonia, acute respiratory distress syndrome, and systemic thromboembolism, resulting in multiple organ failure with high mortality and morbidity. SARS-CoV-2 has immune evasion mechanisms, including inhibition of interferon signaling and suppression of T cell and B cell responses. SARS-CoV-2 infection directly and indirectly causes dysregulated immune responses, platelet hyperactivation, and endothelial dysfunction, which interact with each other and are exacerbated by cardiovascular risk factors. In this review, we summarize current knowledge on the pathogenic basis of

2021-03-14

School of Nursing, Chongqing Medical University, Chongqing, 400016, China.; Department of Epidemiology and Biostatistics, Southwest School of Medicine and First Affiliated Hospital, Army Medical University, Chongqing, 400038, China.; School of Nursing, Chongqing Medical University, Chongqing, 400016, China.; School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China. lww102551@cqmu.edu.cn.; Research Center for Medicine and Social Development, Chongqing, 400016, China. lww102551@cqmu.edu.cn.; Innovation Center for Social Risk Governance in Health, Chongqing, 400016, China. lww102551@cqmu.edu.cn.

OBJECTIVE: To assess perceptions of risk and related factors concerning COVID-19 epidemic among residents in Chongqing city, China. METHODS: With convenience sampling, a web questionnaire survey was conducted among 476 residents living in Chongqing on February 13rd to 14th in 2020, when citizens just started to get back to work. RESULTS: Residents' estimated perceived risks were (4.63 ± 0.57), (4.19 ± 0.76), (3.23 ± 0.91) and (2.29 ± 0.96) for the infectivity, pathogenicity, lethality and self-rated infection possibility of COVID-19, respectively. Females (OR = 4.234), people with income ≥ 2000 yuan (2000-4999 yuan: OR = 5.052, 5000-9999 yuan: OR = 4.301, ≥ 10,000 yuan: OR = 23.459), the married status (OR = 1.811), the divorced status, widows or widowers (OR = 3.038), people living with families including children (OR = 5.085) or chronic patients (OR = 2.423) had a higher perceived risk level, as well as people who used free media websites (OR = 1.756), community workers (OR = 4.064)

Department of Pediatric Hematology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.; Birth Defects Clinical Research Center of Sichuan Province, Luzhou, Sichuan, 646000, People's Republic of China.; Department of Pediatrics, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.; Department of Pediatric Hematology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.; Birth Defects Clinical Research Center of Sichuan Province, Luzhou, Sichuan, 646000, People's Republic of China.; Department of Pediatrics, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.; Department of Pediatric Hematology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.; Birth Defects Clinical Research Center of Sichuan Province, Luzhou, Sichuan, 646000, People's Republic of China.; Department of Pediatrics, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.

Since December 2019, corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, posing a huge threat to human health, and the current epidemic prevention situation is still severe. Hematological parameters directly reflect the damage of SARS-CoV-2 to human blood cells, which can better assess the severity and prognosis of patients infected with COVID-19, but hematological parameters have some differences between adults and children. This article comprehensively reviews the differences in hematological parameters between adults and children after SARS-CoV-2 infection, and provides a reference for the diagnosis and treatment of COVID-19.CI - © 2021 Liu et al.

Department of Cardiology, Beijing Jishuitan Hospital, Peking University Fourth Hospital, Beijing, China.; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing, China.; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing, China.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is a global pandemic. It has resulted in considerable morbidity and mortality around the world. The respiratory system is the main system invaded by the virus involved in COVID-19. In addition to typical respiratory manifestations, a certain proportion of severe COVID-19 cases present with evidence of myocardial injury, which is associated with excessive mortality. With availability of an increasing amount of imaging data, right ventricular (RV) damage is prevalent in patients with COVID-19 and myocardial injury, while left ventricular damage is relatively rare and lacks specificity. The mechanisms of RV damage may be due to increased RV afterload and decreased RV contractility caused by various factors, such as acute respiratory distress syndrome, pulmonary thrombosis, direct viral injury, hypoxia, inflammatory response and autoimmune injury. RV dysfunction usually indicates a poor

2021-07-15

Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong.; Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

BACKGROUND: It has been reported that dyslipidemia is related to coronavirus-related diseases. Critical patients with coronavirus disease 2019 (COVID-19) who suffered from multiple organ dysfunctions were treated in the intensive care unit (ICU) in Wuhan, China. Whether the lipids profile was associated with the prognosis of COVID-19 in critical patients remained unclear. METHODS: A retrospective study was performed in critical patients (N=48) with coronavirus disease 2019 in Leishenshan hospital between February and April 2020 in Wuhan. The parameters including lipid profiles, liver function, and renal function were collected on admission day, 2-3days after the admission, and the day before the achievement of clinical outcome. RESULTS: Albumin value and creatine kinase (ck) value were statistically decreased at 2-3 days after admission compared with those on admission day (P<0.05). Low density lipoprotein (LDL-c), high density lipoprotein (HDL-c), apolipoprotein A (ApoA), and

2021-12-02

Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, China.; Education Bureau of Guangyuan, Sichuan, China.; Mental Health Center of Guangyuan, Sichuan, China.; Mental Health Center of Guangyuan, Sichuan, China.; Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, China. Electronic address: xscat@swu.edu.cn.

BACKGROUND: The COVID-19 pandemic has brought a lot of working stress to medical workers and has a certain impact on their mental health. Working stress is closely related to the increase in anxiety, but few studies have explored whether their relationship will be affected by positive psychological factors in the special situation. METHODS: 798 medical workers were investigated online after the outbreak of the COVID-19 (10 February to 1 March 2020) in China. The relevant questionnaires were used to evaluate working stress, anxiety, sense of control, and psychological capital. The moderated mediation model test was performed using the SPSS software and PROCESS macro program. RESULTS: Working stress could directly affect anxiety, and indirectly affect anxiety through sense of control. In addition, psychological capital moderated the direct effect of working stress on anxiety, which is more effective at high level of psychological capital. Psychological capital also moderated the second

2021-08-10

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macao, China.; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macao, China.; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macao, China.; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macao, China.; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macao, China.

Introduction: The role of pharmacists in public health management is expected to grow into a key player in the continuing measures of managing the COVID-19 pandemic, especially in the community setting. However, their intention to provide essential public health services for combating the pandemic and the impact of their attitude and beliefs are largely unknown. This study aimed to investigate the intention-to-practice COVID-19-related responsibilities of pharmacists based on the theory of planned behavior (TPB), identify the key factors predicting their intention, and explore the usefulness of the TPB model in predicting such an intention. Methods: A cross-sectional, self-administered questionnaire was completed by pharmacists in Macao between May and August 2020. Quantitative responses regarding intention-to-practice COVID-19-related duties, and the four TPB variables [attitude (A), subjective norms (SN), perceived behavioral control (PBC), and past behavior (PB)] were measured.

2021-06-02

Virology Department, Guangzhou Centre for Disease Control and Prevention, Baiyunqu Qidelu 1, Guangdong, China.; Pesticide and Disinfection Department, Guangzhou Centre for Disease Control and Prevention, Baiyunqu Qidelu 1, Guangdong, China.; Virology Department, Guangzhou Centre for Disease Control and Prevention, Baiyunqu Qidelu 1, Guangdong, China.; Epidemiology Department, Guangzhou Centre for Disease Control and Prevention, Baiyunqu Qidelu 1, Guangdong, China.; Epidemiology Department, Guangzhou Centre for Disease Control and Prevention, Baiyunqu Qidelu 1, Guangdong, China.

The dengue fever epidemic in Guangzhou may have been affected by the Coronavirus Disease 2019 (COVID-19) pandemic. The number of dengue cases dropped drastically in 2020, and there have been only 2 local cases, suggesting that dengue has not become endemic in Guangzhou.