2021-03-09

Molecular Medicine Department, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.; Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Pulmonary Medicine, Koc University School of Medicine, Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.; Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.; National Heart and Lung Institute, Imperial College London and the NIHR Imperial Biomedical Research Centre, London, United Kingdom.; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.

In late December 2019, a vtiral pneumonia with an unknown agent was reported in Wuhan, China. A novel coronavirus was identified as the causative agent. Because of the human-to-human transmission and rapid spread; coronavirus disease 2019 (COVID-19) has rapidly increased to an epidemic scale and poses a severe threat to human health; it has been declared a public health emergency of international concern (PHEIC) by the World Health Organization (WHO). This review aims to summarize the recent research progress of COVID-19 molecular features and immunopathogenesis to provide a reference for further research in prevention and treatment of SARS coronavirus2 (SARS-CoV-2) infection based on the knowledge from researches on SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS-CoV).CI - Copyright © 2021 Alipoor, Mortaz, Jamaati, Tabarsi, Bayram, Varahram and Adcock.

2021-10-17

Koç University Research Center for Translational Medicine, Istanbul, Turkey.; Department of Pulmonary Medicine, Koç University Hospital, Istanbul, Turkey.; Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Faculty of Medicine, Lund University, Lund, Sweden.; Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; Koç University Research Center for Translational Medicine, Istanbul, Turkey.; Koç University Research Center for Translational Medicine, Istanbul, Turkey.; Koç Healthcare American Hospital, Istanbul, Turkey.; Marmara University Hospital, Istanbul, Turkey.; Department of Pulmonary Medicine, Koç University Hospital, Istanbul, Turkey.; Department of Pulmonary Medicine, Koç University Hospital, Istanbul, Turkey.; Koç Healthcare American Hospital, Istanbul, Turkey.; Marmara University Hospital, Istanbul, Turkey.; Koç University Research Center for Translational Medicine, Istanbul, Turkey.; Department of Allergy and Immunology, School of Medicine, Koç University, Istanbul, Turkey.; Koç Healthcare American Hospital, Istanbul, Turkey.; Department of Pulmonary Medicine, Koç University Hospital, Istanbul, Turkey.; Department of Radiology, School of Medicine, and.; Department of Infectious Diseases, School of Medicine, Koç University Hospital, Istanbul, Turkey.; Koç University Research Center for Translational Medicine, Istanbul, Turkey.; Koç University Research Center for Translational Medicine, Istanbul, Turkey.; Department of Pulmonary Medicine, Koç University Hospital, Istanbul, Turkey.; Department of Infectious Diseases, School of Medicine, Koç University Hospital, Istanbul, Turkey.; Koç Healthcare American Hospital, Istanbul, Turkey.; Department of Pulmonary Medicine, Koç University Hospital, Istanbul, Turkey.CN - OSACOVID-19 Study Collaborators

Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity, hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea (OSA) is associated with these conditions and may influence the prognosis of adults with COVID-19. Objectives: To determine the effect of OSA on clinical outcomes in patients with COVID-19. Methods: The current prospective observational study was conducted in three hospitals in Istanbul, Turkey from March 10 to June 22, 2020. The participants were categorized as high-risk or low-risk OSA according to the Berlin questionnaire that was administered in the out-patient clinic, in hospital, or shortly after discharge from hospital blinded to the clinical outcomes. A modified high-risk (mHR)-OSA score based on the snoring patterns (intensity and/or frequency), breathing pauses, and morning/daytime sleepiness, without taking obesity and hypertension into account, were used in the regression models. Results: The primary

2021-05-31

Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: kokturk.nurdan@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey. Electronic address: cbabayigit@gmail.com.; Department of Biostatistics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. Electronic address: sevalkul@gantep.edu.tr.; Department of Pulmonary Medicine, University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: pelindurucetinkaya@hotmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Mersin University, Mersin, Turkey. Electronic address: atissibel@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. Electronic address: serapargun2002@yahoo.com.; Department of Pulmonary Medicine, Halil Sıvgın Cubuk State Hospital, Ankara, Turkey. Electronic address: oguzkarcioglu@gmail.com.; Department of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: pinar_aysert@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: ilimirmak@hotmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Ufuk University, Ankara, Turkey. Electronic address: aycnakbas@hotmail.com.; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: yoncahacioglu@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. Electronic address: oyabaydarr@yahoo.com.tr.; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli Turkey. Electronic address: emelazak@mynet.com.; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: saitmoglu@gmail.com.; Department of Pulmonary Medicine, Altunizade Acibadem Hospital, Istanbul, Turkey. Electronic address: caglar.cuhadaroglu@acibadem.com.tr.; Department of Infectious Disease, Kadikoy Florence Nightingale Hospital, Istanbul, Turkey. Electronic address: demirelaslihan@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey. Electronic address: bjkerget1903@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey. Electronic address: burcubaran@hotmail.com.; Department of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: sozger@yahoo.com.; Department of Pulmonary Medicine, Maslak Acibadem Hospital, Istanbul, Turkey; Operating Room Services Department, Nisantasi University, Vocational School, Istanbul, Turkey. Electronic address: gulcihanozkan@gmail.com.; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey. Electronic address: dr.zeynepture@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: begumergan@hotmail.com.; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: vildan.oguz@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: oguz.kilinc@deu.edu.tr.; Department of Pulmonary Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. Electronic address: evrem-33@hotmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: tansu.ciftci@gazi.edu.tr.; Department of Infectious Disease, Faculty of Medicine, Turkiye Gazetesi Private Hospital, Istanbul, Turkey. Electronic address: oalici@gmail.com.; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. Electronic address: dresratemel@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. Electronic address: dr.ozlemozturk@outlook.com.; Department of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey. Electronic address: asenaarisoy@gmail.com.; Department of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey. Electronic address: dilekbahcetepe@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, On Dokuz Mayis University, Samsun, Turkey. Electronic address: tahagullu@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. Electronic address: fusunfakili@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazig, Turkey. Electronic address: fgndeveci@yahoo.com.; Department of Pulmonary Medicine, Bilecik Training and Research Hospital, Bilecik, Turkey. Electronic address: neslihankose.nks@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. Electronic address: meltemtor@gmail.com.; Department of Pulmonary Medicine, University of Health Science, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey. Electronic address: gunluoglu76@yahoo.com.; Department of Pulmonary Medicine, University of Health Science, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey. Electronic address: draltinsedat@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazig, Turkey. Electronic address: teyfikt@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, On Dokuz Mayis University, Samsun, Turkey. Electronic address: tibeltuna@hotmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. Electronic address: dronderozturk@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Taksim, Acibadem University, Istanbul, Turkey. Electronic address: dikensoy@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. Electronic address: pinaryildiz691@hotmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. Electronic address: ilknur.basyigit@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. Electronic address: haboyaci@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: ikoguzulgen@gmail.com.; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: serminborekci@yahoo.com.tr.; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: bilung@gmail.com.; Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: firat.bayraktar@gmail.com.; Department of Pulmonary Medicine, Kadikoy Florence Nightingale Hospital, Istanbul, Turkey. Electronic address: osmanelbek@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. Electronic address: ismailhnt@gmail.com.; Department of Pulmonary Medicine, Altunizade Acibadem Hospital, Istanbul, Turkey. Electronic address: hacerkuzu@hotmail.com.; Department of Pulmonary Medicine, Altunizade Acibadem Hospital, Istanbul, Turkey. Electronic address: gulserensagcan@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, On Dokuz Mayis University, Samsun, Turkey. Electronic address: oguzuzun67@yahoo.com.tr.; Department of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey. Electronic address: akgunm@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey. Electronic address: gaergur@gmail.com.; Department of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey. Electronic address: bernatoraks@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey. Electronic address: ebruckr@yahoo.com.; Department of Thoracic Surgery, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey. Electronic address: egulhan@rocketmail.com.; Department of Pulmonary Medicine, Baskent University, School of Medicine, Ankara, Turkey. Electronic address: fusuneyuboglu@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. Electronic address: o.gultekin@hotmail.com.tr.; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. Electronic address: dyhavlucu@yahoo.com.; Department of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey. Electronic address: metin58@yahoo.com.; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. Electronic address: aysins@hotmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Ege University, Izmir, Turkey. Electronic address: abdullah.sayiner@ege.edu.tr.; Department of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: fuattoraks@gmail.com.; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: oya.itil@deu.edu.tr.; Department of Pulmonary Medicine, Koc University Research Center for Translational Medicine (KUTTAM), Koc University School of Medicine, Istanbul, Turkey. Electronic address: habayram@ku.edu.tr.

The COVID-19-related death rate varies between countries and is affected by various risk factors. This multicenter registry study was designed to evaluate the mortality rate and the related risk factors in Turkey. We retrospectively evaluated 1500 adults with COVID-19 from 26 centers who were hospitalized between March 11 and July 31, 2020. In the study group, 1041 and 459 cases were diagnosed as definite and highly probable cases, respectively. There were 993 PCR-positive cases (66.2%). Among all cases, 1144 (76.3%) were diagnosed with non-severe pneumonia, whereas 212 (14.1%) had severe pneumonia. Death occurred in 67 patients, corresponding to a mortality rate of 4.5% (95% CI:3.5-5.6). The univariate analysis demonstrated that various factors, including male sex, age ≥65 years and the presence of dyspnea or confusion, malignity, chronic obstructive lung disease, interstitial lung disease, immunosuppressive conditions, severe pneumonia, multiorgan dysfunction, and sepsis, were