2021-02-24

Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Nanjing, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; Suzhou Centre for Disease Control and Prevention, Suzhou, China.; Nanjing Centre for Disease Control and Prevention, Nanjing, China.; Huaian Centre for Disease Control and Prevention, Huaian, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Nanjing, China.; Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.; NHC Key Laboratory of Enteric Pathogenic Microbiology, Nanjing, China.

To understand the characteristics and influencing factors related to cluster infections in Jiangsu Province, China, we investigated case reports to explore transmission dynamics and influencing factors of scales of cluster infection. The effectiveness of interventions was assessed by changes in the time-dependent reproductive number (Rt). From 25th January to 29th February, Jiangsu Province reported a total of 134 clusters involving 617 cases. Household clusters accounted for 79.85% of the total. The time interval from onset to report of index cases was 8 days, which was longer than that of secondary cases (4 days) (χ2 = 22.763, P < 0.001) and had a relationship with the number of secondary cases (the correlation coefficient (r) = 0.193, P = 0.040). The average interval from onset to report was different between family cluster cases (4 days) and community cluster cases (7 days) (χ2 = 28.072, P < 0.001). The average time interval from onset to isolation of patients with secondary

2021-11-15

Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.; NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Key Laboratory of Infectious Diseases, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

To assess the persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies produced by natural infection and describe the serological characteristics over 7 months after symptom onset among coronavirus disease 2019 (COVID-19) patients by age and severity group, we followed up COVID-19 convalescent patients confirmed from 1 January to 20 March 2020 in Jiangsu, China and collected serum samples for testing IgM/IgG and neutralizing antibodies against SARS-CoV-2 between 26 August and 28 October 2020. In total, 284 recovered participants with COVID-19 were enrolled in our study. Patients had a mean age of 46.72 years (standard deviation [SD], 17.09), and 138 (48.59%) were male. The median follow-up time after symptom onset was 225.5 (interquartile range [IQR], 219 to 232) days. During the follow-up period (162 to 282 days after symptom onset), the seropositive rate of IgM fluctuated around 25.70% (95% confidence interval [CI], 20.72% to 31.20%) and that of IgG